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LAZAROS I. SAKKAS

MD, ECFMG(USA), DM, PhD(UK), FRCP(UK)

Long and vast experience in pathology, in arthritis, in arthritis and systemic autoimmune diseases

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The medical specialist in rheumatic and autoimmune diseases

Μακρόχρονη και τεράστια εμπειρία σε παθήσεις της παθολογίας, στις αρθρίτιδες και στα συστηματικά αυτοάνοσα νοσήματα από την μετεκπαίδευση και εργασία μου σε Ελλάδα, Αγγλία (United Medical and Dental Schools, Guy’s Hospital, London) και Αμερική (Temple University, Philadelphia, PA, USA).

Με την ανάληψη της Διεύθυνσης της Ρευματολογίας στο Πανεπιστημιακό Γενικό Νοσοκομείο Λάρισας από την αρχή της λειτουργίας του τo 2000, πέτυχα, με τη βοήθεια των Συνεργατών μου, να βάλω τη Ρευματολογική κλινική του νοσοκομείου στο διεθνή χάρτη και στη μεγάλη εκτίμηση των ασθενών.

Lazaros I Sakkas, MD, ECFMG(USA), DM, PhD (UK), FRCP (UK)
Specialist in Internal medicine and Rheumatology
Professor of Internal Medicine and Rheumatology, Faculty of Medicine, Shool of Health Sciences, University of Thessaly, Larissa, Greece
Formerly, Chairman, Department of Rheumatology and Clinical Immunology, University General Hospital of Larissa

OTHER POSITIONS:

  • Adjunct Assistant Professor, Temple University School of Medicine, Philadelphia, PA, USA
  • Adjunct Professor, Old dominion University, Norfolk, VA, USA
  • Fellow of the Royal College of phycisians (FRCP)(Hon) (London)(2015-)

DEGREES AND SPECIALIZATIONS

  • MD degree, National and Kappodistrian University of Athens

  • ECFMG Certificate, USA

  • Title of Specialty in Internal Medicine, Ministry of Health, Greece 

  • Diploma in vascular diseases, Helenic Angiology Society (1984)

  • Didactoriko (PhD) degree, National and Kappodistrian University of Athens

  • PhD degree, London University, London, UK 

  • Title of Specialty in Rheumatology, Ministry of Health, Greece 

CLINICAL APPOINTMENTS

  • After specialization in Internal Medicine (Greece).

  • Visitor for one month, Department of Medicine, Ottawa University General Hospital, Ottawa, Canada

  • Registrar in Rheumatology and Research Assistant/Associate, Rheumatology Unit, Division of Medicine, and Department of Immunogenetics, United Medical and Dental schools of Guy’s and St’Thomas’ Hospitals (UMDS), Guy’s Hospital, London SE1 UK and PhD student(1985-1991)

  • Assistant Professor of Medicine, Head of 3rd division, Department of Internal Medicine, University General Hospital of Ioannina, Ioannina, Greece(1991-1995)

  • Research Assistant Professor, Department of Medicine/Rheumatology, Temple University School of Medicine, Philadelphia, PA, USA (1994-1999)

  • -Head of Rheumatology Division and Head of the 2nd Department of Internal Medicine (1999-2008) and then

  • Chairman, Department of Rheumatology (renamed Rheumatology and Clinical Immunology) (2008-Sept 2018), University General Hospital of Larissa, Larissa, Greece

ACADEMIC APPOINTMENTS

  • Research Associate, Rheumatology Unit and Department of Immunogenetics, United Medical and Dental Schools, Guy’s Hospital, London, UK (1986-90)

  • Assistant Professor, University of Ioannina Medical School, Ioannina, Greece (1990-95)

  • Research Assistant Professor, Temple University School of Medicine, Philadelphia, PA, USA (1994-99)

  • Professor, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa (1998-Sept 2018), and Chairman, Department of Rheumatology, Unversity General Hospital of Larissa

EDITORIAL DUTIES

  • Editor, Hellenic Rheumatology and then Mediterranean Journal of Rheumatology (for many years)

  • Editor, Front Immunol

  • Editor Int J Rheumatol

  • Guest Editor Curr Rheumatol Rev: systemic sclerosis

  • Guest Editor (Bogdanos DP, Sakkas LI, Shonfeld Y) Diet and rheumatic diseases. Mediterr J Rheumatology 2020

  • Editorial Board member in several English language Journals

EDITOR in BOOKS

  • Updates in the diagnosis and treatment of vasculitis. Ed L.I. Sakkas, C.Katsiari, InTech

  • New developments in the pathogenesis of rheumatoid arthritis. Ed L.I. Sakkas, InTech

CLINICAL TRIALS

  • I participated as Principal Investigator in many multicenter clinical trials

CLINICAL AND RESEARCH INTEREST

Special interest in systemic autoimmune diseases, (systemic sclerosis, systemic lupus erythematosus, myositides), arthritides, T cells, B cells, HLA, cytokines, autoantibodies autoimmune diseases. Environmental factors in autoimmunity. Foremost priority is early diagnosis and early institution of the most appropriate treatment for patients with rheumatic diseases.  

INVITED SPEAKER

I gave many lectures in national and international scientific meetings, seminars, and Congresses.

PUBLICATIONS:

Many abstracts have been presented in meetings. Mosts of there appeared as full-papers.

Synopsis: 180 English language papers, 16 English chapters in English language books, 67 Greek language papers

Citation Index:7196, h-index= 45,  i10-index=119

PUBLICATIONS:

            Sakkas LI, Thouas B, Kotsou S, Apostolou A, Ioakimides D.  Cervical myelopathy with ankylosing hyperostosis of the spine. Surg Neurol 1985; 24:43-6.

            Sakkas LI, Thouas B, Smyrnis P, Vlahos E. Low-back pain and ochronosis. 

Intern Orthop 1987; 11:19-21.

            Sakkas LI, Demaine AG, Welsh KI, Panayi GS. Restriction fragment length polymorphism for the T-cell receptor α and β chain genes in rheumatoid arthritis.

Arthritis Rheum 1987; 30:231-2.

            Wordsworth BP, Lanchbury JSS, Sakkas LI, Welsh KI, Panayi GS, Bell JI. HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the human leukocyte antigen class II region.

Proc Natl Acad Sci (USA) 1989;86: 10049-53.

            Sakkas LI, Loqueman N, Panayi GS, Myles AB, Welsh KI. Immunogenetics of polymyalgia rheumatica. Br J Rheumatol 1990; 29:331-4. This prompted an editorial (BJR 29:321-4)

            Sakkas LI, Vaughan RW, Panayi GS, Welsh KI. The application of polymerase chain reaction (PCR) to HLA-C locus typing.  Eur J Immunogenet 1991;18: 185-87.

            Sakkas LI, Marchesoni A, Kerr L-A, Ranza R, Colombo B, Welsh KI, Panayi GS. Immunoglobulin heavy chain gene polymorphisms in Italian patients with psoriasis and psoriatic arthritis.   Br J Rheumatol 1991;30: 449-50.

            Sakkas LI, Chikanza IC, Vaughan RW, Welsh KI, Panayi GS. Gold-induced nephropathy in rheumatoid arthritis and HLA class II genes. Ann Rheum Dis 1993;52: 300-1.

            Sakkas LI, Kistis C, Akritidis NK. Anti-neutrophil cytoplasmic autoantibodies in HIV infection.   Am J Kidney Dis 1994;24: 731.

            Sakkas LI, Platsoucas CD.  Immunopathogenesis of juvenile rheumatoid arthritis: role of T cells and MHC. Immunol Res 1995;14: 218-36.

            Akritidis NK, Sakkas LI. Adult onset Still’s disease in Greece-16 cases.

Presse Med 1995; 24(26): 1207-8.

            Sakkas LI, Moore D, Akritidis NK. Cancer in families with systemic sclerosis.

Am J Med Sci 1995;310: 223-25.

            Akritidis N, Yannakakis Y, Sakkas L. Very high serum ferritin levels in adult onset Still’s disease. Br J Rheumatol 1997;36: 608-9.

            Sakkas LI, Johanson NA, Scanzello CR, Platsoucas CD. Interleukin 12 is expressed by infiltrating macrophages and synovial lining cells in rheumatoid arthritis and osteoarthritis.  Cell Immunol 1998;188: 105-10.

            Sakkas LI, Scanzello CR, Katsetos CD, Johanson NA, Burkholder J, Mitra A, Salgame P, Platsoucas CD. T cells and T-cell cytokine transcripts in the synovial membrane in patients with osteoarthritis. Clin Diagn Lab Immunol 1998;5: 430-37. This prompted an editorial.

            Sakkas LI, Tourtellotte C, Berney S, Myers AR, Platsoucas CD.  Increased levels of alternatively spliced interleukin-4(IL-4δ2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosis.  Clin Diagn Lab Immunol 1999;6: 660-66. This prompted an editorial.

            Chikanza IC, Sakkas L. Advances in the therapy of rheumatoid arthritis with biological agents. Expert Opinion on Emerging Drugs 2000;5: 367-84.

Xu B, Sakkas LI, Slachta C, Jeevanandam V, Goldman B, Oleszack E, Platsoucas CD.  Apoptosis in chronic rejection of human cardiac allografts. Transplantation 2001;71: 1137-46.

            Sakkas LI, Platsoucas CD. Role of T cells in the pathogenesis of osteoarthritis. Arthritis Rheum 2002; 46: 3112-13.

            Sakkas LI, Xu B, Artlett CA, Lu S, Jimenez SA, Platsoucas CD. Oligoclonal T cell expansion in the skin of patients with systemic sclerosis. J Immunol 2002;168: 3649-59.

            Derk CT, Sakkas LI, Rasheed M, Artlet C, Jimenez SA. Autoantibodies in patients with systemic sclerosis and cancer: a case control study. J Rheumatol 2003;30: 1994-6.   

            Xu B, Sakkas LI, Goldman BI, Jeevandam V, Gaughan J, Oleszak EL, Platsoucas CD. Identical α-chain T-cell receptor transcripts are present on T cells infiltrating coronary arteries of human cardiac allografts with chronic rejection. Cell Immunol 2003;225: 70-85.

Sakkas LI, Koussidis G, Avgerinos E, Platsoucas CD. Decreased expression of CD3ζ-chain in T cells infiltrating the synovial membrane of patients with osteoarthritis. Clin Diagn Lab Immunol 2004;11: 195-202.

            Sakkas LI, Platsoucas CD.  Is systemic sclerosis an antigen-driven T cell disease? Arthritis Rheum 2004; 50: 1721-33.

            Kalogirou A, Gelou E, Mountantonakis S, Settas L, Zafiriou E, Sakkas LI. Early T cell activation in the skin from patients with systemic sclerosis. Ann Rheum Dis 2005;64:1233-35. 

Sakkas LI.  New developments in the pathogenesis of systemic sclerosis. Autoimmunity 2005;38:113-16. Editorial.

            Sakkas LI, Chikanza IC, Platsoucas CD. Mechanisms of disease: the role of immune cells in the pathogenesis of systemic sclerosis. Nature Clin Pract Rheum 2006;2: 679-85 This is the 6th most read paper in 2006

            Sakkas LI, Platsoucas CD. The role of T cells in the pathogenesis of osteoarthritis. Arthritis Rheum 2007;56:409-24.

            Alexiou I, Germenis A, Ziogas A, Theodoridou K, Sakkas LI. Diagnostic value of anti-citrullinated peptide antibodies in Greek patients with rheumatoid arthritis.  BMC Musculoskel Dis 2007;8: 37-43

            Sakkas LI, Boulbou M, Kyriakou D, Makri I, Sinani C, Germenis A, Stathakis N. Immunological features in visceral leishmaniasis may mimic systemic lupus erythematosus. Clin Biochem 2008;41:65-68

            Alexiou I, Germenis A, Koutroumbas A, Kontogianni A, Theodoridou K, Sakkas LI. Anti-cyclic citrullinated peptide-2(CCP2) antibodies and extra-articular manifestations in Greek patients with rheumatoid arthritis. Clin Rheumatol 2008;27:511-3

            Davas EM, Alexiou I, Boulbou M, Koutroumpas A, Makaritsis K, Stathakis N, Sakkas LI. Co-morbidities increase the risk of serious infections in patients with rheumatoid arthritis treated with TNFa inhibitors. J Infect 2008;57:418-20

            Sakkas LI, Davas EM, Kapsalaki E, Boulbou M, Makaritsis K, Alexiou I, Tsikrikas T, Stathakis N. Haematogenous spinal infection in central Greece. Spine 2009;34:E513-8

            Vlychou M, Koutroumpas A, Malizos K, Sakkas LI. Ultrasonographic evidence of inflammation is frequent in hands of patients with erosive osteoarthritis. Osteoarthritis and Cart. 2009;17: 1283-7.

            Koutroumbas A, Alexiou I, Vlychou M, Sakkas LI. Comparison of clinical and ultrasonographic assessment in patients with erosive osteoarthritis. Clin Rheumatol. 2010;29:511-6

            Anagnostopoulos I, Zintzaras E, Alexiou I, Papathanasiou AA, Davas E, Koutroumpas A, Barouta G, Sakkas LI. The prevalence of rheumatic diseases in central Greece: a population survey. BMC Musculoskelet Disord 2010;11:98-106.

            Koutroumpas A, Ziogas A, Alexiou I, Barouta G, Sakkas LI. Mycophenolate mofetil in systemic sclerosis-associated interstitial lung disease. Clin Rheum 2010; 29:1167-8.

            Vlychou Μ, Koutroumpas Α, Alexiou Ι, Fezoulidis Ι, Sakkas LI. High-resolution Ultrasonography and 3.0T Magnetic Resonance Imaging in erosive and nodal hand osteoarthritis: high frequency of erosions in nodal osteoarthritis. Clin Rheum 2013;32(6):755-62

            Sakkas LI, Alexiou I, Simopoulou T, Vlychou M. Enthesitis in psoriatic arthritis. Semin Arthritis Rheum 2013;43(3):325-34

            Mavropoulos A, Rigopoulou EI, Liaskos C, Bogdanos DP, Sakkas LI. The role of p38 MAPK in the aetiopathogenesis of psoriasis and  psoriatic arthritis. Clin Develop Immunol 2013;2013:569751

            Koutroumpas A, Giannoukas A, Zintzaras E, Exarchou E, Baliakos A, makaritsis K, Sakkas LI. Erosive hand osteoarthritis is associated with subclinical atherosclerosis and endothelia cell dysfunction. Int J Biomed Sci 2013; 9(4):217-23

            Sakkas LI, Bogdanos DP, Katsiari C, Platsoucas CD. Citrullinated peptides as autoantigens in rheumatoid arthritis-relevance to treatment. Autoimmun Rev 2014;13(11):1114-20. 

            Sakkas LI. Editorial. Mediterranean journal of Rheumatology: New title, new look, new targets.

            Sakkas LI, Vaiopoulos G. The new 2013 ACR/EULAR classification criteria for systemic sclerosis pave the way for treatment in pre-scleroderma patients. Mediterr J Rheumatol 2015;26:15-6

            Sakkas LI, Mavropoulos A, Bogdanos DP. Regulatory B cells open new therapeutic strategies for autoimmune diseases. Mediterr J Rheumatol 2015;26:64-67

            Simopoulou T, Varna A, Dailiana Z, Katsiari C, Alexiou I, Basdekis G, Malizos KN, Sakkas LI. Tuberculous pyomyositis; a re-emerging entity of many faces. Clin Rheumatol 2016;35:1105-10. 

            Mavropoulos A, Simopoulou T, Varna A, Liaskos C, Katsiari C, Bogdanos DP, Sakkas LI.  B regulatory cells are numerically decreased and functionally impaired in patients with systemic sclerosis. Arthritis Rheumatol. 2016;68(2): 494-504.

            Sakkas LI, Bogdanos DP. Systemic sclerosis: new evidence re-enforces the role of B cells.. Autoimmun Rev 2016;15(2):155-61

            Sakkas LI, Daoussis D, Liossis S-NC, Bogdanos DP. Regulatory B cells: New players in rheumatic diseases. Clin Rev Allergy Immunol 2016.

            Sakkas LI. Spotlight on tocilizumab and its potential in the treatment of systemic sclerosis: the evidence todate. Drug Des Dev Ther 2016;10: 2723-28.

            Sakkas LI, Perricone C, Bogdanos DP. Rheumatoid arthritis: an interplay of genetic and environmental factors. J Immunol Res.

            Sakkas LI, Bogdanos DP. Infections as a cause of autoimmune rheumatic diseases. Auto Immun Highlights 2016;7(1):13

            Sakkas LI. Regulatory B cells in autoimmune rheumatic diseases. Mediterr J Rheumatol 2017;28:27-31.      

          Sakkas LI, Bogdanos DP. Are psoriasis and psoriatic arthritis the same disease? The IL-23/IL-17 axis data. Autoimmun Rev 2017;16(1):10-15. Doi:10.1016/j.autrev.2016.09.015.

            Botou A, Bangeas A, Alexiou I, Sakkas LI. Acro-osteolysis. Clin Rheumatol 2017;36(1):9-14

            Marou E, Liaskos C, Simopoulou T, Efthymiou G, Dardiotis E, Katsiaric C, Scheper T, Meyer W, Hadjigeorgiou G, Bogdanos DP, Sakkas LI. Human cytomegalovirus (HCMV) UL44 and UL57 specific antibody responses in anti-HCMV positive patients with systemic sclerosis. Clin Rheumatol 2017;36(4):863-69.

            Bogdanos DP, Sakkas LI. From microbiome to infetome in autoimmunity. Curr Opin Rheum 2017;29(4):369-73.

            Mavropoulos A, Varna A, Zafiriou E, Alexiou I, Roussaki-Shulze A, Katsiari C, Bogdanos DP, Sakkas LI.  IL-10-producing ells are impared in psoriatic arthritis and psoriasis and inversely correlate with IL-17- and IFNγ-producing T ccells. Clin Immunol 2017;184:33-41.

            Sakkas LI, Mavropoulos A, Bogdanos DP.  Phosphodiesterase 4 inhibitors in immune mediated diseases: mode of action, clinical applications, future perspectives. Curr Med Chem 2017;24(28):3054-67.

            Liaskos C, Marou E, Simopoulou T, Barmakoudi M, Efthimiou G, Scheper T, Meyer W, Bogdanos DP, Sakkas LI. Disease-related autoantibody profile in patients with systemic sclerosis. Autoimmunity 2017;50(7):414-21.

            Sakkas LI, Daoussis D, Liossis S-N, Bogdanos DP. The infectious basis of ACPA-positive rheumatoid arthritis. Front Microbiol 2017;8:1853

            Kelepouri D, Mavropoulos A, Bogdanos DP, Sakkas LI. The role of flavonoids in inhibiting Th17 responses in inflammatory arthritis. J Immunol Res 2018;2018:9324357

            Sakkas LI, Simopoulou T, Daoussis D, Liossis S-N, Potamianos S. Intestinal involvement in systemic sclerosis. A clinical review. Dig Dis Sci 2018;63(4):834-44.

            Sakkas LI, Bogdanos DP. Multiple hit infection and autoimmunity: the dysbiotic microbiota-ACPA connection in rheumatoid arthritis. Curr Opin Rheum 2018;30(4):403-409.

            Simopoulou T, Klimopoulos S, Sampaziotis D, Tzotrziotis A, Bogdanos DP, Sakkas LI.  Retroperitoneal IgG4-related disease causing inferior vena cava thrombosis: case report and literature review. JSRD 2018;

            Sakkas LI, Mavropoulos A, Perricone C, Bogdanos DP. IL-35: a new immunoregulator in autoimmune rheumatic diseases. Immunol Res 2018;66(3):305-312.

            Katsiari C, Simopoulou T, Alexiou I, Sakkas LI. Immunotherary of scleroderma. Hum Vaccines Immunother 2018;14(11):2559-67

            Asteriou E, Gkoutzourelas A, Mavropoulos A, Katsiari C, Sakkas LI, Bogdanos DP. Curcumin for the Management of Periodontitis and Early ACPA-Positive Rheumatoid Arthritis: Killing Two Birds with One Stone.  Nutrients 2018 Jul 16;10(7).  

            Gkoutzourelas A, Liaskos C, Mytilinaiou MG, Simopoulou T, Katsiari C, Tsirogianni A, Daoussis D, Liossis S-N, Scheper T, Meyer W, Bogdanos DP, Sakkas LI. Anti-Ro60 seropositivity determines anti-Ro52 epitope mapping in patients with systemic sclerosis, Front Immunol 2018;9:2835.

            Sakkas LI, Daoussis D, Mavropoulos A, Liossis S-N, Bogdanos DP. Regulatory B cells: New players in inflammatory and autoimmune rheumatic diseases. Semin Arthritis Rheum 2019;48(6):1133-1141.

            Katsiari CG, Bogdanos DP, Sakkas LI. Inflammation and cardiovascular disease. World J Transl Med 2019;8(1):1-8

            Sakkas LI, Trontzas P. The Greek (Hellenic) rheumatology over the years: From ancient to modern times.  Rheumatol Int 2019

            Liaskos C, Rentouli S, Simopoulou T, Gkoutzourelas A, Norman GL, Brotis A, Alexiou I, Katsiari C, Bogdanos DP, Sakkas LI. Anti-C1q autoantibodies are frequently detected in patients with systemic sclerosis associated with pulmonary fibrosis. Br J Dermatol. 2019 Jul;181(1):138-146. doi: 10.1111/bjd.17886

            Mavropoulos A, Zafiriou E, Simopoulou T, Brotis AG, Liaskos C, Roussaki-Schulze A, Katsiari CG, Bogdanos DP, Sakkas LI. Apremilast increases IL-10-producing regulatory B cells and decreases proinflammatory T cells and innate cells in psoriatic arthritis and psoriasis. Rheumatology (Oxford). 2019;58(12):2240-2250. doi: 10.1093/rheumatology/kez204

            Sakkas LI, Zafiriou E, Bogdanos DP. New treatments in psoriatic arthritis. Focus on the IL-23/IL-17 axis. Front Pharmacol 2019;10:872.

            Efthymiou G, Dardiotis E, Liaskos C, Marou E, Scheper T, Meyer W, Daponte A, Daoussis D, Hadjigeorgiou G, Bogdanos DP, Sakkas LI. A comprehensive analysis of antigen-specific antibody responses against human cytomegalovirus in patients with systemic sclerosis.  Clin Immunol. 2019;207: 87-96

            Gkoutzourelas A, Bogdanos DP, Sakkas LI. Kawasaki disesae and COVID-19. Mediter J Rheumatol 2020;31(Suppl 2):268-74

            Stamatis P, Bodganos DP, Sakkas LI. Upadacitinib tartrate for rheumatoid arthritis. Drugs Today(Barc) 2020;56(11):723-32.

            Sakkas LI, Bogdanos DP. The role of T cells in systemic sclerosis: An update. IMMUNO 2022;2: 534-47.

            Sakkas LI, Katsiari C, Daoussis D, Bogdanos DP. The role of B cells in the pathogenesis of systemic sclerosis: an update. This prompted an Editorial. Rheumatology 2023

            Sakkas LI, Chikanza IC. Editorial.Sex bias in immune responses: It is time to include the sex variable in studies of autoimmune rheumatic diseases Rheumatol Int 2023

BOOKS AND CHAPTERS IN ENGLISH BOOKS

  1. Sakkas LI. Molecular immunogenetic studies in rheumatic diseases. PhD thesis, London University. London 1990.
  2. 2. Lanchbury JSS, Sakkas LI, Panayi GS. Genetic factors in rheumatoid arthritis. In Rheumatoid arthritis. Smolen, Kalden, Maini, eds. Springer-Verlag, Berlin, 1992, pp 17-28.Nova 2011
  3. Katsiari C, Salkkas LI. Treatment of ANCA-associated vasculitis. In Advances in diagnosis and treatment of vasculitis. Ed, LM Amezcua-Guerra, INTECH 2011
  4. Koutroumpas A, Simipoulou T, Sakkas LI. Pharmacological treatment of osteoarthritis.In Arthritis: types, treatment, and prevention. Ed. MN Pelt, New York, Nova Science Publications, 2012.
  5. Katsiari C, Simopoulou T, Sakkas LI. Treatment of non-ANCA smal vessel vasculitis. In Advances in the Diagnosis and treatment of vasculitis. Sakkas LI, Katsiari C, Editors, InTech 2013
  6. Sakkas LI, Alexiou I. Scleroderma, treatment (current and upcoming).  In Encyclopedia of Medical Immunology. Autoimmune diseases. Mackay IR, Rose NR Eds- in- Chief, Springer 2014.
  7. Bogdanos DP, Smyk DS, Sakkas LI, Shoenfeld Y. Microbiota and autoimmunity. In Infection and autoimmunity, Editors: Y. Shoenfeld, N.Agmon-Levin, N.R.Rose, 2nd edition, Academic Press, Elsevier, pp 149-63, 2015.
  8. Smyk DS, Sakkas LI, Shoenfeld Y, Bogdanos DP. Hepatitis B vaccination and autoimmunity. In Vaccines and Autoimmunity, Ed Y. Shoenfeld, N. Agmon-Levine, L. Tomljenovic, pp 147-62, 2015, Wiley, ISBN:9781118663431
  9. Sakkas LI, Bogdanos DP. DNA viruses and autoimmune rheumatic diseases. In: The microbiome-infection and rheumatic diseases. Ferguson Eds, Springer 2018
  10. Bogdanos DP, Sakkas LI. Chapter 21. Infections: Viruses and bacteria. In Mosaic of Autoimmunity Ed Perricone C, Shoenfeld Y, Elsevier 2019
  11. Sakkas L. Systemic sclerosis. In: Absolute Rheumatology Review Ed P Efthimiou, Springer Nature Switzerland 2020; pp263-275
  12. Efthimiou G, Sakkas LI, Bogdanos DP. Heat shock proteins as target autoantigens in autoimmune rheumatic diseases. In: Heat shock proteins, AAA Asea, P.Kaur (eds) Springer Nature https://doi.org/10.1007/7515–2020–35.
  13. Sakkas LI, Simopoulou T. T cells in the pathogenesis of systemic sclerosis. In Translational Autoimmunity. Chapter 22 Ed N Rezaei, Academic Press 2023, pp447-474.
  14. Efthimiou G, Sakkas LI, Bogdanos DP. Heat shock proteins as autoantigens in autoimmune rheumatic diseases. In Heat Shock proteins, Editon-in-Chief:AAA Asea, Springer 2020
  15. Mavropoulos A, Zafiriou E, Dardiotis E, Sakkas LI, Bogdanos DP. B regulatory cells in patients with autoimmune diseases. Pathogenic significance and therapeutic potential. Translational Autoimmunity Vol2, Chapter 3, Elsevier 2021.
  16. Goutzourelas A, LIaskos C, Mytilinaiou MG, Simopoulou T, Katsiari C, Tsirogianni A, Daoussis D, Bogdanos DP, Sakkas LI. Anti-Ro60 seropositivity determines anti-Ro52 epitope mapping in patients with systemic sclerosis. In Key players in systemic sclerosis: the immune system and beyond. Eds: Guilpain P, Noel D, Avouac J. Frontiers 2021. doi: 10.3389/978-2-88971-744-6
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